ULAM Pathology Core

Oversight is provided by board-certified, veterinary pathologists with extensive experience in research pathology. Technical staff have certification and/or experience in histology or animal health related fields. Only projects utilizing animal tissues or de-identified (research only) human tissues are supported. Quality assurance is maintained through the use of internal SOPs and participation in an externally administered quality assurance program.

The ULAM Pathology core provides only pathology-based services. For technical assistance with live animal procedures, please see the ULAM Technical Services team.

ULAM Pathology Core Missions: Research & Diagnostic Support

• Research submissions: ULAM Pathology Core research support services are available on a recharge basis by direct submission to ULAM Pathology Core. Recharge rates are approved by the University and are based upon cost-recovery. Estimates and letters of support are available and pre-project consultation is encouraged. See Service Areas below for available services, rates, and submission instructions.
• Animal Diagnostic submissions: ULAM Pathology Core also provides diagnostic pathology services to the veterinary care program. These services are for the identification of unanticipated animal illnesses and are not recharged to the investigator. Results are provided to the researcher, but diagnostic pathology reports are not intended to provide controlled research data. Diagnostic pathology services are available by contacting the ULAM Veterinary Care Team.
• Our main laboratory is located on the ground floor of B36 in the North Campus Research Complex (NCRC) and our satellite facility is in the MSAB building on the Medical Campus. Samples may be dropped off/picked up by appointment at either location with daily sample courier service between the campuses.

ULAM Pathology Core Services

Expand each section below for service details and rates, or request services in MiCORES.

Necropsy/Tissue Collection

• Rodent and large animal necropsy or tissue collection by ULAM Pathology Core personnel
• Use of large or small animal necropsy room for necropsy by investigators
• Tissue trimming and cassetting for histology by ULAM Pathology Core personnel
• Necropsy RATES

Histology/Immunohistochemistry

• Paraffin processing/embedding
• Frozen and paraffin sectioning
• Hematoxylin and eosin staining and special histochemical stains
• Immunohistochemistry (IHC)
• Self-service frozen sectioning (animal tissues only)
• Histology/Immunohistochemistry RATES

Clinical Pathology: Animal Hematology/Clinical Chemistry & Diagnostic Testing

• Clinical pathology: Animal hematology/clinical chemistry & diagnostic testing
• Complete blood counts (CBC) using Heska HT5 Element (Heska)
• Serum chemistry using Liasys analyzer (AMS Alliance)
• Cytology, including blood smears
• Other testing: Urinalysis, parasitology
• Biological indicator verification (sterility strip verification)
• Microbiology and other diagnostic services (through external laboratories)
• Clinical Pathology RATES

Digital Slide Scanning & Digital Image Analysis

• Digital slide scanning using Leica Aperio AT2® scanner
• Publication-quality images
• Digital slide files suitable for image analysis and quantitative morphometry
• Digital slides scanning RATES

Pathology Interpretation & Quantitative Image Analysis

• Digital slide scanning using Leica Aperio AT2® scanner
• Publication-quality images
• Digital slide files suitable for image analysis and quantitative morphometry
• Digital slides scanning RATES

Request ULAM Pathology Core Services in MiCORES

Necropsy
Histology
Pathology
Digital Slide Scanning

request services

ULAM Pathology Core MiCORES Submission Guide

Step-by-step help for account setup, lab membership, payment methods, submitting service requests, and more. Available via PDF download.

download the guide

ULAM Clinical Case Submissions

Submit clinical case samples to the ULAM Pathology Core for processing.

ULAM Employees Only

submit samples

ULAM Pathology Core Frequently Requested Information

Expand each section below for additional information.

Sample Submission Steps & Guidelines

ULAM Pathology Core Lab Submissions (Necropsy, Histology, Clinical Pathology, Slide Scanning, Pathology): 1-2-3

Submit a request in MiCORES for any of the following services:

• Necropsy, Histology, and Pathology Requests
• Digital Scanning Requests
• Clinical Pathology Lab Requests
• Outside Laboratory Requests (shipping samples to an outside lab)

In the request, note your sample drop-off date/time and location preferences. An appointment will be scheduled for you by the ULAM Pathology Core Team.

WAIT for a confirmed appointment, then bring your samples in a clean secondary container at the time of your appointment. Label your samples with the Service ID from your request (as found in your appointment confirmation email).

ULAM Pathology Core Sample Submission Guidelines

• Hematology and Clinical Chemistry Sample Guidelines
• Digital Slide Scanning Sample Guidelines
• Histology Sample Guidelines
• Immunohistochemistry (IHC) Sample Guidelines
• Necropsy Sample Guidelines

Location & Hours of Operation

Samples may be dropped off at either location (below) by appointment only. Submit your request for services in MiCORES and note your sample drop-off date/time and location preference. An appointment will be scheduled for you by the ULAM Pathology Core Team.

Sample courier service is available daily between the two locations. Please email at least 24 hours in advance for hematology/chemistry requests.

Two weeks’ notice is requested for Research Necropsy Requests. Diagnostic necropsy requests (for spontaneous conditions unrelated to research) are made through the ULAM Veterinary Care Team.

Main: B36/G157A, NCRC

Monday – Friday
9:00 AM – 4:00 PM

2800 Plymouth Road
Ann Arbor, MI 48109

(734) 936-3395

ulam-pathologycore@umich.edu

Satellite: 3527 MSAB

Monday – Friday
9:00 AM – 3:00 PM

1150 W. Medical Center Drive
Ann Arbor, MI 48109

(734) 936-3803

ulam-pathologycore@umich.edu

Rates

ULAM Pathology Core – Necropsy Rates

DESCRIPTION

RATE

EFFECTIVE

Tissue Preparation

Trim/Cassette (Paraffin or OCT)

$ 12.71

07/01/2023

Decalcification (tissue in cassette)

$ 11.00

07/01/2023

Decalcification (larger tissue)

$ 15.84

07/01/2023

Necropsy

Fixed Animal Necropsy

$ 86.48

07/01/2023

Small Animal Necropsy

$ 79.38

07/01/2023

Medium Animal Necropsy

$ 166.32

07/01/2023

Large Animal Necropsy

$ 354.82

07/01/2023

Large Animal Biohazard Necropsy

$ 468.47

07/01/2023

Necropsy Technician Labor/Hour Regular

$ 60.00

07/01/2023

Necropsy Technician Labor/Hour Overtime

$ 90.00

07/01/2023

Special considerations apply for projects with internal Medical School funding or to Mouse Metabolic Phenotyping Consortium members; please inquire.

ULAM Pathology Core – Histology Rates

DESCRIPTION

RATE

EFFECTIVE

Standard Histology Procedures

Paraffin Processing & Embedding

$ 6.34

07/01/2023

Paraffin Unstained Slides (Specials or IHC)

$ 6.00

07/01/2023

Paraffin H&E Slide Simple^{^^} (section & stain)

$ 8.00

07/01/2023

Paraffin H&E Slide Complex⁺⁺ (section & stain)

$ 12.00

07/01/2023

H&E Stain only (slide provided by PI)

$ 5.62

07/01/2023

Frozen H&E Slide (section & stain)

$ 15.48

07/01/2023

Frozen Unstained Slide (return unstained)

$ 14.08

07/01/2023

Frozen Unstained Slide (Specials or IHC)

$ 14.08

07/01/2023

Paraffin Unstained Slide Simple^{^^} (return unstained)

$ 6.00

07/01/2023

Paraffin Unstained Slide Complex⁺⁺ (return unstained)

$ 9.00

07/01/2023

Histology Technician Labor/Hour Regular

$ 60.00

07/01/2023

Histology Technician Labor/Hour Overtime

$ 90.00

07/01/2023

Cryostat (self-service)/Hour

$ 11.50

07/01/2023

^{^^}Simple: visceral organs (kidney, liver, etc.), up to two sections per slide, skin, or GI (non-step, non-serial)

⁺⁺Complex: step sections, serial sections (>2), >2 of any tissue per slide, bone sections, non-rodent brain sections, specialized tissue targets (cardiac valve leaflets, etc.)

Immunohistochemistry Stains

IHC aSMA

$ 42.38

07/01/2023

IHC CD45R-B220

$ 42.38

07/01/2023

IHC CD3

$ 42.38

07/01/2023

IHC CD4

$ 48.50

07/01/2023

IHC CD8a

$ 48.50

07/01/2023

IHC CD20

$ 42.38

07/01/2023

IHC CD31

$ 48.50

07/01/2023

IHC Cleaved Caspase-3

$ 42.38

07/01/2023

IHC F4/80

$ 42.38

07/01/2023

IHC GFP

$ 42.38

07/01/2023

IHC Ki67

$ 42.38

07/01/2023

IHC Ly-6G

$ 42.38

07/01/2023

IHC Lyve-1

$ 42.38

07/01/2023

IHC Mac2

$ 42.38

07/01/2023

IHC Von Willebrand Factor

$ 48.50

07/01/2023

IHC Negative Control

$ 44.83

07/01/2023

IHC Stain, Paraffin, Other (antibody provided by PI)

$ 44.83

07/01/2023

IHC Stain, New Antibody Optimization Slide

$ 52.18

07/01/2023

IHC Stain, Frozen, Other (antibody provided by PI)

$ 50.95

07/01/2023

Special Histochemical Stains

Special Stain Gram

$ 49.25

07/01/2023

Special Stain Luxol Fast Blue (LFB)

$ 49.25

07/01/2023

Special Stain Masson Trichrome (MTC)

$ 20.00

07/01/2023

Special Stain Masson Trichrome Verhoeff (MTCV)

$ 28.15

07/01/2023

Special Stain Other

$ 42.22

07/01/2023

Special Stain Picrosirius Red (PSR)

$ 28.15

07/01/2023

Special Stain Prussian Blue

$ 42.22

07/01/2023

Special Stain Toluidine Blue

$ 28.15

07/01/2023

Special Stain Verhoeff Van Gieson (VVG)

$ 49.25

07/01/2023

Special Stain Alcian Blue (AB)

$ 28.15

07/01/2023

Special Stain Alcian Blue PAS (AB-PAS)

$ 49.25

07/01/2023

Special Stain Alizarin Red

$ 42.22

07/01/2023

Special Stain Congo Red

$ 42.22

07/01/2023

Special Stain Luxol Fast Blue PAS (LFB-PAS)

$ 49.25

07/01/2023

Special Stain Oil Red O (ORO)

$ 42.83

07/01/2023

Special Stain Periodic Acid Schiff (PAS)

$ 28.15

07/01/2023

Special Stain Ziehl Neelson

$ 49.25

07/01/2023

Special considerations apply for projects with internal Medical School funding or to Mouse Metabolic Phenotyping Consortium members; please inquire.

ULAM Pathology Core – Animal Clinical Pathology Laboratory Testing Rates

DESCRIPTION

RATE

EFFECTIVE

1 Chemistry Only/ Animal

$ 26.48

07/01/2023

Custom Panel, 2 Chemistries/Animal

$ 43.04

07/01/2023

Custom Panel, 3 Chemistries/Animal

$ 54.61

07/01/2023

Custom Panel, 4 Chemistries/Animal

$ 63.68

07/01/2023

Custom Panel, 5 Chemistries/Animal

$ 72.23

07/01/2023

Add-on (to panel), One Chemistry

$ 7.58

07/01/2023

Animal Clinical Pathology Laboratory Technician Labor/Hour Regular

$ 60.00

07/01/2023

Animal Clinical Pathology Laboratory Technician Labor/Hour Overtime

$ 90.00

07/01/2023

ADS – C. Difficile ELISA

$ 85.51

07/01/2023

ADS – C. Perfringens ELISA

$ 65.62

07/01/2023

ADS – Clostridia ELISA

$ 111.34

07/01/2023

ADS – Fecal Culture

$ 63.63

07/01/2023

ADS – General Culture

$ 79.53

07/01/2023

ADS PCR for SRV

$ 169.02

07/01/2023

ADS – Urine Culture

$ 71.57

07/01/2023

ADS – Urine Culture & Susceptibility

$ 71.57

07/01/2023

Anaerobic Culture

$ 52.48

07/01/2023

Blood Culture & Susceptibility

$ 117.38

07/01/2023

Blood Smear (prep only)

$ 14.39

07/01/2023

Complete Blood Count (CBC) w/ Auto Differential

$ 28.48

07/01/2023

Direct Smear for Parasites

$ 32.84

07/01/2023

Ectoparasite Exam, Microscopic

$ 13.18

07/01/2023

Electrolytes

$ 25.63

07/01/2023

Fecal Culture & Susceptibility

$ 104.65

07/01/2023

Fecal Flotation

$ 43.22

07/01/2023

Full Chemistry Panel

$ 74.78

07/01/2023

Fungal Culture

$ 62.11

07/01/2023

General Culture & Susceptibility

$ 91.96

07/01/2023

Hematocrit, Spun

$ 19.78

07/01/2023

Herpes B Cell Culture, Virology

$ 292.63

07/01/2023

Herpes B Serology – Antibody

$ 156.07

07/01/2023

Insulated Sample Transport Box

$ 30.25

07/01/2023

Laboratory Sendout Processing Fee

$ 28.41

07/01/2023

Liver Panel

$ 53.99

07/01/2023

Manual (WBC) Differential

$ 40.68

07/01/2023

McMasters Fecal Exam

$ 26.02

07/01/2023

Mini Chem Panel

$ 54.66

07/01/2023

Mini Liver Panel

$ 30.60

07/01/2023

Pig Full Chemistry Panel

$ 80.08

07/01/2023

PT/PTT

$ 75.76

07/01/2023

Renal Panel

$ 38.95

07/01/2023

Reticulocyte Count

$ 41.14

07/01/2023

Room Temp Sample Transport Box

$ 14.61

07/01/2023

Total Protein, Refractometer

$ 23.10

07/01/2023

Urinalysis, Complete

$ 48.26

07/01/2023

Urinalysis, Routine

$ 46.91

07/01/2023

Verify Ampule (autoclave control)

$ 22.91

07/01/2023

Special considerations apply for projects with internal Medical School funding or to Mouse Metabolic Phenotyping Consortium members; please inquire.

The facilities are operated on a fee-for-service basis. Users are charged based on the amount of time technicians spend performing the services.

ULAM Pathology Core – Aperio^® Digital Slide Scanning Rates

DESCRIPTION

RATE

EFFECTIVE

Digital slide scan, Technician Labor/Hour Regular

$ 60.00

07/01/2023

Digital slide scan, Technician Labor/ Hour Overtime

$ 90.00

07/01/2023

Digital slide scan, 20x, batch >50 slides, each

$ 8.00

07/01/2023

Digital slide scan, 20x, batch 20-50 slides, each

$ 10.00

07/01/2023

Digital slide scan, 20x, <20 slides, each

$ 12.00

07/01/2023

Digital slide scan, 40x, batch >50 slides, each

$ 9.00

07/01/2023

Digital slide scan, 40x, batch 20-50 slides, each

$ 11.00

07/01/2023

Digital slide scan, 40x, <20 slides, each

$ 13.00

07/01/2023

ULAM Pathology Core – Pathologist Rates

DESCRIPTION

RATE

EFFECTIVE

ULAM Pathology Core Pathologist Hourly Rate

$ 250.00

07/01/2023

*Rates subject to change.

ULAM Pathology Core Authorship/Acknowledgment Policies